However, we did observe a significantly enhanced cytotoxicity of the NK-92 cell line (but not the KHYG-1, NKL and NK-YS cell line, data not shown) toward the AML cell lines Molm-13 and HL-60 but not the pediatric BCP-ALL cell line Nalm-16 in the presence of the TIGIT-blocking mAb (p ≤ 0.05) (Fig. 4B, D and F). This evidence concerns the gene TIGIT and acute lymphoblastic leukemia.