In line with the notion that fundamental phenotypical differences exist between adult and pediatric B-cell precursor lymphatic leukemia with respect to cell adhesion molecules and MHC class I ligands [40–42], we currently assume that the functional significance of the TIGIT-CD112/CD155 axis might also significantly differ between AML and pediatric BCP-ALL. This evidence concerns the gene NECTIN2 and acute myeloid leukemia.