In line with the notion that fundamental phenotypical differences exist between adult and pediatric B-cell precursor lymphatic leukemia with respect to cell adhesion molecules and MHC class I ligands [40–42], we currently assume that the functional significance of the TIGIT-CD112/CD155 axis might also significantly differ between AML and pediatric BCP-ALL. The gene discussed is PVR; the disease is acute myeloid leukemia.