Anti PD‐1/PDL‐1 are generally better tolerated: in the metanalysis from Wang more common irAEs were diarrhea (9.47%), hypothyroidism (6.07%), and transaminase elevation (3.39%); grade >3 events were transaminase elevation (0.75%), pneumonia (0.67%) and diarrhea (0.59%); a trend to higher incidence of grade ≥3 irAEs seems to emerge for anti‐PD‐1 as compared to anti‐PD‐L1.5 Here, CD274 is linked to pneumonia.