FZD2 and Robinow syndrome: As multiple genes are involved, the pathogenesis of Robinow syndrome could result from an imbalance of either branch of WNT signaling pathways, as we recently reported for DVL1 variants (Gignac et al., 2023) and others for reported variants in FZD2 (Liegel et al., 2023; Zhu et al., 2023).