FZD2 and Robinow syndrome: Our approach involved introducing avian-specific replication-competent retroviruses [replication-competent avian sarcoma-leukosis virus (ASLV) long terminal repeat with a splice acceptor (RCAS)] (Hughes, 2004) containing wild-type (wt) or variant human (h) FZD2 into the frontonasal mass (Fig. 1A), a facial prominence most affected in patients with Robinow syndrome.