CRP demonstrated predictive ability of initial antibiotics against infection at 24 h (T2), 48 h (T3), and 72 h (T4), with the optimal cutoff value of 156.6 mg/L (AUC = 0.724, 95% CI 0.549–0.900, sensitivity 50%, and specificity 90.5%), 46.87 mg/L (AUC = 0.741, 95% CI 0.580–0.902, sensitivity 93.8%, and specificity 52.4%), and 66.21 mg/L (AUC = 0.797, 95% CI 0.622–0.971, sensitivity 92.3%, and specificity 64.3%), respectively (Figure 2B). Here, CRP is linked to infection.