Loss of autoimmune capacity and tumorigenesis of GBM CSCs, which may be strongly linked to ALDH1A3 expression, were caused by decreased USP9X, which in turn lowered ALDH1A323 Furthermore, it was found that the USP9X WP1130 inhibitor had a substantial impact on ALDH1A3 degradation and demonstrated promising therapeutic results in models of orthopedic xenograft transplantation produced from GBM CSCs.23 This evidence concerns the gene ALDH1A3 and glioblastoma.