In conclusion, the significant contribution of our study lies in the introduction of novel biomarkers; circRNAs; circ-TubD1 (circ-0044897), circ-CDC27 (circ-0044235), and circ-Med14 (circ-0140271), miRNA (rno-miR-146a-5p), and mRNA (TRAF6) that may play a potential role in the development of SLE. Here, TUBD1 is linked to systemic lupus erythematosus.