MED14 and rheumatoid arthritis: In addition, circ-0140271, a circRNA generated from the mediator complex subunit 14 (MED14) gene located on the X-chromosome, was suggested as a potential diagnostic biomarker for the chronic autoimmune disease; rheumatoid arthritis (RA), as it may act as miRNA sponge to regulate fatty acid metabolism pathways in RA [15].