The analysis revealed that the circ-RNAs: circ-CDC27 (circ-00442315), circ-Med14 (circ-0140271), circ-TubD1 (circ-0044897), and rno-miR-146a-5p had the potential to discriminate rats with SLE from control group with AUC of 0.9922 (P=0.0009), 0.8906 (P=0.008), 0.915 (P=0.017), and 0.905 (P=0.002), respectively, as shown in Figure 3. The gene discussed is CDC27; the disease is systemic lupus erythematosus.