In the current study, data of ROC curve analysis of the circRNAs: circ-CDC27 (circ-0044235), circ-Med14 (circ-0140271), circ-TubD1 (circ-0044897), and rno-miR-146a-5p suggests that they could be useful as SLE diagnostic biomarkers. Here, TUBD1 is linked to systemic lupus erythematosus.