Therefore, the aim of the present study was to determine the role of novel non-invasive diagnostic RNA biomarkers as circRNAs; circ-TubD1 (circ-0044897), circ-CDC27 (circ-0044235), and circ-Med14 (circ-0140271), in addition to the miRNA (rno-miR-146a-5p) and mRNA (TRAF6) in SLE-induced rats. This evidence concerns the gene CDC27 and systemic lupus erythematosus.