NFAT5 and preeclampsia: Of interest, placental expression of several Na+ channels was reported to be reduced in preeclampsia, such as epithelial Na+ channel and NHE-3 (sodium–hydrogen exchanger 3), a finding in line with the compromised aldosterone availability of preeclampsia.46–48 Strong redundancy of Na+-induced TonEBP activation was present in trophoblasts unaffected by inhibiting single Na+ channels, including epithelial Na+ channel.