REN and preeclampsia: Plasma active renin concentrations were different between groups (P<0.05), with the highest in nonpregnant women (P<0.05; Figure 1C), when compared with normotensive pregnancy; women with preeclampsia had even lower plasma active renin concentrations (P<0.0001), a difference that was maintained when subgrouped by early-onset preeclampsia only (Figure 1C).