A positive difference of 1 year of age, a CD4+ T-cell count <350 cells/mm3, and type 2 diabetes were significantly associated with worsening to frailty, in both crude and multivariable analyses considering gender, age at baseline, college education level, and period of HIV diagnosis (adjusted odds ratio [aOR], 1.10; 95% CI, 1.01–1.20; aOR, 3.05; 95% CI, 1.14–8.18; and aOR, 2.63; 95% CI, 1.05–6.57; respectively). The gene discussed is CD4; the disease is type 2 diabetes mellitus.