CD4 and type 2 diabetes mellitus: Advanced age, baseline CD4+ T-cell count <350 cells/mm3, and type 2 diabetes were associated with transition from prefrailty to frailty (adjusted odds ratio [aOR], 1.10 per 1-year positive difference; 95% CI, 1.01–1.20; aOR, 3.05; 95% CI, 1.14–8.18; and aOR, 2.63; 95% CI, 1.05–6.57; respectively).