Using an integrative computational approach informed by in-vivo neuroimaging of AD patients and cognitively unimpaired (CU) subjects negative for both Aβ and tau, along with ex-vivo neurotypical whole-brain transcriptomics, we investigated neuronal activity alterations induced by both Aβ and tau pathologies in AD and mapped their spatial overlap with neurotypical gene expression. This evidence concerns the gene MAPT and Alzheimer disease.