In AD, exosomes from neurons and glial cells disseminate pathogenic amyloid-β and tau proteins, promoting their aggregation and disruption of vital neuronal processes including axonal transport (Rajendran et al., 2006; Dinkins et al., 2014; Joshi et al., 2014, 2015; Liu et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.