Next, by considering the urine albumin to creatinine ratio (ACR), we divided the healthy, T2D − DN, and T2D + DN cohort into 3 groups: one with healthy (ACR < 30 mg/g), microalbuminuria (30 < ACR < 300 mg/g), or macroalbuminuria/late renal disease (ACR > 300 mg/g). Here, ALB is linked to type 2 diabetes mellitus.