Moreover, in PWH and CMV coinfection, in vitro stimulation of PBMCs with CMVpp65 in the presence of IL-27 stimulation led to increased IFNγ secretion by CMVpp65-specific CD4 T cells in both CMV+PWH and CMV+PWOH (People Without HIV) (113, 123). The gene discussed is IL27; the disease is coinfection.