Interestingly, in the Sb9 KO tumors in Sb9 KO mice, there are increased ratios of CD8+, CD44+CD62L-CD8+, TNFα+CD8+, GzmB+CD8+, and IFNγ+CD8+, as compared with those from the WT tumor in WT mice (30). This evidence concerns the gene IFNG and neoplasm.