A recent validation study on functional SNPs and outcome after chemotherapy in colorectal carcinoma showed that the P2RX7 GOF SNP rs208294 (C489T) was associated with worse overall survival (OS) and progression free survival, however the P2RX7 LOF SNP rs2230911 (C1096G) was prognostic and predictive, showing improved OS in patients who received oxaliplatin (53). The gene discussed is P2RX7; the disease is colorectal carcinoma.