• Identified Cluster 1 tumor cells expressed high levels of genes linked to tumor metastasis.• communication between terminally exhausted CD8+ T cells and GDF15hiATF3hiCDKN1Ahi tumor cells was enhanced in BAP1-mutated UM and CellChat analysis predicting strong ITGB2-ICAM1 signaling between• The inhibitors that inhibited hypoxia- and ECM-related pathways could prevent liver metastasis in the BAP1-mutated group. Here, ITGB2 is linked to neoplasm.