IFNG and neoplasm: Similarly, Wu et al. (2021) elucidated the effect of silibinin on the tumor immune microenvironment and showed that the administration of liposomal silybin shifted the TME from a “cold” into a “hot” tumor via an increment in the infiltration of CTLs; also, liposomal silybin enhanced IFN-γ but diminished TGF-β levels.