AR and hepatocellular carcinoma: Androgens also have been demonstrated to upregulate the proliferation of HCC cells by activating their receptor AR, which in turn promotes the expression of c-Myc, an important regulator of cell proliferation and survival (Bao et al., 2020; Cho et al., 2020; Cui et al., 2020; Zhu et al., 2020; Gao et al., 2021) (Supplementary Table S1).