For example, KLHDC5 and CDKAL1 are not only associated with femoral neck bone mineral density (BMD) (FN_BMD) (p-value of KLHDC5 = 1.90E−12, p-value of CDKAL1 = 2.70E−13) (Estrada et al., 2012) but also with T2DM (p-value of KLHDC5 = 6.1E−10, p-value of CDKAL1 = 6.00E−36) (Voight et al., 2010; Morris et al., 2012). This evidence concerns the gene CDKAL1 and type 2 diabetes mellitus.