Then, based on the LASSO algorithms, we identified six hub genes, namely, LGALS2, LTB, STEAP4, TPBG, VGF, and VNN1. Next, we verified the expression of these central genes in T2DM and OP mouse models and patients using RT-PCR, immunofluorescence, Western blot, and ELISA. The gene discussed is STEAP4; the disease is type 2 diabetes mellitus.