PRKD1 and gonorrhea: Taking into account the high sequence identity shared among the kinase domain between PRKD1, PRKD2, and PRDK3, together with some subsets of PACs that exhibit an absence of somatic mutations at the PRKD1 hotspot or rearrangements within the gene family such as those found in low-grade PACs also known as PLGAs, it was hypothesized that alternative oncogenic mechanisms to mutation E710D in PDRK1 may influence other members of the gene family, thus playing a role in pathogenesis related to PAC, according to Piscuoglio et al. [64].