PKC has been demonstrated to be upregulated in ALS models and to trigger NMJ disintegration (Dobrowolny et al., 2018b; Camerino et al., 2019) and it is involved in nAChR clustering and NMJ formation (Lanuza et al., 2001; Lanuza et al., 2002; Martinez-Pena y Valenzuela et al., 2013). This evidence concerns the gene PRRT2 and amyotrophic lateral sclerosis.