These results suggested that B. velezensis CFS treatment also stimulated several detoxification-related pathways in C. fioriniae, such as glutathione metabolism and pathways involving the ABC and MFS transporter protein families, to reduce the damage caused by B. velezensis CFS and promote the formation of complex interactions between C. fioriniae and B. velezensis CFS. This evidence concerns the gene ABCB6 and myalgic encephalomeyelitis/chronic fatigue syndrome.