Moreover, two genes encoding LETM-1 ribosome binding proteins, which regulate mitochondrial integrity, the production of endogenous reactive oxygen species and mycotoxin biosynthesis (Natarajan et al., 2021), were downregulated by the B. velezensis CFS, further suggesting potential target genes for B. velezensis CFS. Here, LETM1 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.