BECN1 and infection: 1. Inhibit the secretion of pro-inflammatory cytokines;2. Stimulate the receptor-induced expression of antimicrobial peptides, up-regulate LL37 gene to induce the autophagy related proteins Atg5 and Beclin-1 to mediate the killing effect;3. Reduce the expression of MMP-7, −9 and − 10, eliminate tissue damage and relieve symptoms of infection;4. Activate the receptor of vitamin D, reduce Mtb-induced bone destruction by inhibiting NF-κB signaling.