MMP1 and tuberculosis: 1. Increase the production of mROS in host cells and the acidification of mycobacterium phagosome,;promote the proliferation of T cells secreting IFN-γ;2. Reduce the soluble CD14, CD163, CRP, and MMP-1, −2, −3, −7, −9, −12 levels;3. Induce autophagy, regulate oxidative stress, and enhance the efficacy of anti-TB drugs.