1. Inhibit the secretion of MMP-1 and − 3, down-regulate type I/II interferon and innate immune response genes, up-regulate B cell related genes;2. Inhibited the growth and activity of Mtb containing teT-off promoter-related genes in TB mice;3. Reduce the activity of type 1 collagenase and elastin in the sputum of TB patients. The gene discussed is SGCG; the disease is tuberculosis.