CYP2J2 is also overexpressed in ovarian cancer and lung cancer metastases [131, 133], and its inhibition by terfenadine-related compounds has been shown to suppress the proliferation of human cancer cells both in vitro and in vivo, which implies that CYP2J2 expression is part of a protective mechanism for cancer cell survival. The gene discussed is CYP2J2; the disease is lung cancer.