HAVCR1 and acute kidney injury: Importantly, novel biomarkers of kidney injury, such as kidney injury molecule-1 (KIM-1) and insulin like growth factor binding protein 7 (IGFBP7) have been shown to predict moderate-severe AKI several hours prior to increased serum creatinine, and serial measurements of IGFBP7 have been shown to respond to clinical management (Fiorentino et al., 2020).