Elevated levels of RBP4 attract macrophages to adipose tissue and promote local inflammation by causing macrophages to secrete pro-inflammatory cytokines: nuclear factor κ-B (NFκB), c-Jun N-terminal kinases (JNK), and interleukin 1β, leading to insulin resistance (Yang et al., 2005). This evidence concerns the gene NFKB1 and Insulin resistance.