↓ Viability of cancer cells, ↑ nuclear and chromatin condensation, ↑ Bcl-2-associated X (Bax), ↑ c-polyadenosine-diphosphate-ribose polymerase (PARP), ↓ Bcl-2, ↑ light chain 3 (LC3), ↑ beclin 1, ↑ autophagic vacuoles, ↑ acidic vesicular organelles, ↓ p-mTOR, ↓ p-70-kDa ribosomal protein S6 kinase (P70S6K), ↓ p-S6K, ↓ p-eIF4E-binding protein (4EBP1). The gene discussed is NGDN; the disease is cancer.