↓ Tumor spheroid formation and growth, inhibited PC-3 tube formation, ↓ HIF-1α, ↓ VE-cadherin (under normoxic as well as hypoxic conditions), ↓ Ki-67, ↓ SPHK-1, ↓ cyclin D1, ↓ c-caspase-3, ↓ VEGF. This evidence concerns the gene SPHK1 and neoplasm.