↓ Cancer cell viability, ↑ nuclear condensation and shrinkage, ↑ apoptotic bodies, ↑ c-PARP, ↑ Bax, ↓ Bcl-2, ↑ LC3-II, ↑ beclin 1, ↓ sequestosome 1 (p62), ↓ p-mTOR, ↓ p-extracellular signal-regulated kinases 1/2 (ERK1/2), ↑ p-Jun N-terminal kinase (JNK), ↑ p-p38. The gene discussed is MAPK8; the disease is cancer.