↓ Tumor volume, ↓ vascular segments, ↓ vascular network length, ↓ VEGF-A, ↓ phosphorylated histone H2AX on Serine 139 (pS139-H2AX), ↓ HIF-1α, ↓ Nrf1, ↓ superoxide dismutase 1 (Sod1), ↓ peroxiredoxin 4 (Prdx4), ↓ glutathione peroxidase (Gpx). The gene discussed is HIF1A; the disease is neoplasm.