↓ Tumor growth, ↓ Ki-67, ↑ apoptosis frequency, ↓ MMP-1, 2, 3, 9, 10, and 13, ↑ MMP-8, ↓ tissue inhibitor of metalloproteinase-1 (TIMP-1), ↓ PI3K, ↓ p-Akt, ↓ GSK-3β, ↓ NF-κB. The gene discussed is MKI67; the disease is neoplasm.