CDK4 and Familial prostate cancer: Orm is also reported to arrest cell cycle in G0–G1 phase via modulation of regulatory proteins [such as induction of P21/P27 and inhibition of myeloid cell leukemia-1 (Mcl-1), cyclin D1 and cyclin-dependent kinase 4 (CDK4)], which helps to induce apoptosis, inhibit growth and metastatic potential of prostate cancer cells [5].