BRCA1 and neoplasm: Christie et al. [82] conducted a prospective study in 30 patients with HGSOC carrying a germline BRCA1/2 mutation and detected BRCA1/2 reversion mutations in the tumor in 31.3% of patients treated in the recurrent setting, among which 18.8% also had detectable BRCA1/2 reversions in cfDNA [82].