VIM and lung adenocarcinoma: Since vimentin is required for early-stage lung adenocarcinoma dissemination by acting as a regulator of the motility of tumor-associated fibroblasts [57], the observed decrease in vimentin protein expression in anti-GPC1 mAb-treated LL97A lung fibroblast monoculture and in mouse lung tissues implicates that the anti-GPC1 mAb may inhibit the fibroblasts-led collective invasion of tumor cells [58].