Furthermore, around one-third of oral tongue squamous cell carcinomas cases had CAF expressing neurogenic locus notch homolog protein 3 (NOTCH3), which was positively correlated with the size of the tumor and linked to an augmentation in microvessel density, indicating that Notch signalling in CAF could also promote tumor angiogenesis (Kayamori et al., 2016). The gene discussed is NOTCH3; the disease is neoplasm.