In a recent analysis of EQA data on the current quality of the tumor markers alpha-feto protein (AFP) and carcinoembryonic antigen (CEA), for which there are international reference standard materials, we found a better level of standardization between 2018 and 2022 compared to that reported in 2005 (Wojtalewicz et al., 2023). The gene discussed is AFP; the disease is neoplasm.