Additionally, patients carrying CHRNA4 or CHRNB2 mutations have a higher frequency of cognitive impairment, intellectual disability, and schizophrenia-like symptoms (47), whereas patients carrying CHRNA2 mutations exhibit paroxysmal arousal, occasional nocturnal wandering, and episodic panic attacks; however, these seizures do not correlate with specific sleep stages, which may be related to α2-nAChR distribution in the brain (2). Here, CHRNA4 is linked to Intellectual disability.