DEPDC5 and sleep-related hypermotor epilepsy: DEPDC5 mutation-related SHE was also associated with a high drug resistance rate (13/22, 59%), incomplete penetrance, diurnal onset (3/26), FCD (primarily FCDIIb) (6/26), and SUDEP (6/26), with the latter possibly associated with early epilepsy onset, high drug resistance rates, and predominantly nocturnal seizures in patients (17).