Previous studies have shown that GABAAR α3 peptide aggravates anxiety‐like behaviors in rats by impairing GABAergic transmission, while downregulation of SNO‐gephyrin increases the number of GABAAR cluster.[8, 22] To determine whether the reduction of S‐nitrosylation could produce anxiolytic effect and reverse the decreased surface expression of GABAAR γ2, sulfhydryl‐reducing reagents dithiothreitol (DTT) was used to inhibit S‐nitrosylation of proteins in the BLA of rats. This evidence concerns the gene GPHN and Anxiety.