For example, previous studies have shown that S‐nitrosylation of cyclin‐dependent kinase 5 inhibits neurotoxicity and autophagy in a mouse model of Parkinson's disease.[41] Increased S‐nitrosylation of mitochondrial complex I by nitrite is protective against Parkinson's disease.[42] Aberrant transnitrosylation triggers excessive mitochondrial fragmentation in Alzheimer's disease.[43, 44] Our present study suggests that protein S‐nitrosylation is involved in the generation of anxiety‐like behaviors. This evidence concerns the gene CDK5 and early-onset autosomal dominant Alzheimer disease.