GPHN and Anxiety: Several novel denitrosylases have been identified, including glutaredoxin,[49] thioredoxin‐related protein of 14 kDa,[50] and thioredoxin.[51] However, due to the limited use of these enzymes in vivo, we did not perform in vivo experiments to explore whether these endogenous enzymes could abolish the effect of SNO‐gephyrin on GABAAR trafficking, GABAergic transmission and anxiety‐like behaviors.