Gephyrin, GABAAR‐related protein (GABAARAP) and collybistin can directly interact with GABAAR to regulate GABAAR clustering.[47, 48] Changes in the nitrosylation of gephyrin may also indirectly cause changes in GABAAR γ2 membrane expression by affecting its binding strength to GABAARAP, collybistin and neuroligin‐2, thereby regulating anxiety‐like behaviors. The gene discussed is GPHN; the disease is Anxiety.