IGHE and Alzheimer disease: AD has been hypothesized to reduce the risk of developing cancer through its overactive immune states. Pathogenesis associated with the development of AD is accompanied by the predominance of Type 2 helper T (Th2) cell immunity, highly expressed thymic stromal lymphopoietin (TSLP), and immunoglobulin E (IgE)‐mediated hypersensitivity.47