mTORC1 suppresses the function of the ring finger protein 168 (RNF168) protein and increases its decomposition through phosphorylating the 60th serine which results in diminished ubiquitination of histone H2A and H2A histone family member X (H2AX) following DNA damage, inhibiting the response to DNA damage and decreasing genome stability, promoting malignant cell transformation and cancer development [35]. Here, H2AX is linked to cancer.