In this manuscript, we have applied the same strategy to interrogate the AR to identify PGx-eQTL SNP-gene pairs induced by either androgens (dihydrotestosterone [DHT]) or Enz, which have been reported to induce reprogramming of chromatin and to induce an alternative cistrome as compared to an androgen-inducible cistrome [20–22], to integrate with our previous BC GWAS data with the goal of identifying silent non-coding genetic risk variants important in breast cancer. The gene discussed is AR; the disease is breast carcinoma.