As shown in Fig. 7F, G, LOC101928222 or HMGCS2 knockdown reduced tumor-initiating capacity of CRC cells in nude mice, overexpression of HMGCS2 or IGF2BP1 could rescue the tumor-initiating capacity of LOC101928222 or HMGCS2-knockdown CRC cells. The gene discussed is HMGCS2; the disease is colorectal carcinoma.