We subsequently found that LOC101928222 or HMGCS2 or IGF2BP1 knockdown reduced cholesterol synthesis in CRC cells, and overexpression of HMGCS2 or IGF2BP1 could rescue the decrease cholesterol synthesis of LOC101928222 or HMGCS2-knockdown (Fig. 7C). Here, HMGCS2 is linked to colorectal carcinoma.