Compared to individuals without NAFLD/MASLD, patients with the diagnosis of NAFLD/MASLD, irrespective of which criteria were used, were more likely to be older, Mexican American, married, higher metabolic indexes (including BMI, WC, TG, HbA1c, glucose, insulin, HOMA-IR, and TyG-related indices), lower HDL-C, higher levels of non-invasive liver fibrosis scores, and more likely to have low income, high sedentary lifestyle, diabetes, and hypertension, while they were less likely to have a higher education or be a current smoker (p < 0.017). The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.