ESR1 and breast carcinoma: Given our findings of GNA13 regulation of the expression of several key players of ER+ breast cancer pathogenesis such as MYC and ERα that are well known to correlate to resistance to anti-estrogen treatments and emergence of Long-Term Estrogen Deprivation (LTED) characteristics, the impact of Gα13 on aspects of endocrine resistance in this subtype will be an important area for future investigations.