TBX2 and cancer: Ectopic expression of TBX2 in mammary epithelial cells induces changes in molecular, behavioral and morphological characteristics of EMT, including epithelial adhesion, loss of expression of polarity-related genes (β-catenin, E-cadherin, and Zona occludens 1 [ZO1]), abnormal increases in mesenchymal marker levels (N-cadherin and vimentin), and increased cell motility and cancer invasion [48].