TBX5 and cancer: TBX22 deserves further exploration as a potential target for governance based on its tumor suppressor properties TBX5 has an inhibiting effect on cancer cells by upregulating MTSS I-BAR Domain Containing 1 (MTSS1) or suppressing the expression of the pro-metastatic gene Metastasis Associated 1 Family Member 2 (MTA2) [57].