In HCC, TBX19 forms a transcriptional complex with protein arginine methyltransferase 1 (PRMT1), eliciting epigenetic histone H4R3me2a/ H3K9ac-mediated transactivation of Mitochondrial Fission Factor (MFF), which prevents reactive oxygen species (ROS)-mediated degradation of the pluripotent transcription factor OCT4, leading to enhanced tumor formation and cellular self-renewal [80]. The gene discussed is PRMT1; the disease is hepatocellular carcinoma.