The TBX2-CoREST complex catalyzes the closure of chromatin around the target promoter via LSD1 demethylation and HDAC1/2 deacetylation, inhibiting tumor suppressor targets (Long Intergenic Non-Protein Coding RNA 111 [LINC00111], NDRG1, and Cystatin E/M [CST6]); The TBX2- KRAB associated protein 1(KAP1)- Heterochromatin Protein 1 (HP1) complex drives G9A-dependent H3K9 methylation and interacts with early growth response factor 1 (EGR1) to inhibit NDRG1 [76–78]. This evidence concerns the gene TBX2 and neoplasm.