In 293T cells, different molecules bind to TBX18 to enhance transcriptional repression [Core-Binding Factor Subunit Beta (CBFB), Chromodomain Helicase DNA Binding Protein 7 (CHD7), and IKAROS Family Zinc Finger 2 (IKZF2)] or to alleviate transcriptional repression [Nuclear Receptor Coactivator 5 (NCOA5) and Strawberry Notch Homolog 2 (SBNO2)] [75], suggesting that the expression of cofactors may be associated with TBX18-related ureter development and urological diseases. Here, IKZF2 is linked to urinary system disorder.