This is achieved either via ACE2, CD147, CD26, LFA-1, neuropilin 1 (NRP1) and/or toll-like (TLRs) receptors, expressed mainly on activated T-cells [19–22].These abovementioned mechanisms are not mutually exclusive and can work together resulting in lymphopenia progression in SARS-CoV-2 infection. This evidence concerns the gene NRP1 and lymphopenia.