CD147 was found to play a functional role in facilitating SARS-CoV invasion of HEK 293 cells, and CD147 antagonist peptide-9 inhibited SARS-CoV infection [255].The similarity between SARS-CoV and SARS-CoV-2, the causative agent of COVID-19 urged investigating the role of this receptor in SARS-CoV-2 entry into the human cells. This evidence concerns the gene BSG and severe acute respiratory syndrome.