GDM is considered to have an impact on placental development and function, the expression of parathyroid hormone-related protein (PTH-rP) and its receptor PTH-R1 in placenta are higher in GDM pregnant women with abnormal OGTT at fasting glucose compared to women with abnormal 60’ or 120’ glycemia, and the incidence of neonatal 1-minute Apgar score < 7 is higher in placental PTH-rP positive GDM women [27]. The gene discussed is PTH; the disease is gestational diabetes.