To investigate this a critical issue, the aim of this research is to evaluate the NLRP3 (rs10754558) gene polymorphism, the serum level of CRP and TNFα in psoriasis patients and assessment of the NLRP3 (rs10754558) gene polymorphism, CRP and TNFα with disease severity and their role as biomarkers for response to Methotrexate and Adalimumab in psoriasis. The gene discussed is CRP; the disease is psoriasis.