While the cyst fluid is rich in various growth factors and inflammatory mediators, including interleukin (IL)1 A, IL1B, IL6, IL10, C-X-C motif chemokine ligand (CXCL) 1, CXCL8, and tumor necrosis factor-alpha (TNF) [9, 10], and these two studies did not reveal which specific substances play a role in promoting obesity. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.