New-onset postoperative obesity was associated with high expressions of CXCL1 (Fig. 2C; uOR = 3.67; 95% CI, 1.11–12.15; P = 0.034) and TNF (Fig. 2C; uOR = 2.92; 95% CI, 1.04–9.02; P = 0.045). The gene discussed is CXCL1; the disease is obesity due to melanocortin 4 receptor deficiency.