Similarly, GWAS of Factor 16 captures known lipid biology, with many of the 33 significant loci mapped to core lipid metabolism genes such as LPA, LPL, LDLR, SORT1, APOE and PCSK9 (Fig. 3d), and exhibits strong genetic correlation with a previous coronary artery disease GWAS33 (rg = 0.87[0.02]; InterceptGcov = 0.42[0.01]; UKB-excluded rg = 0.81[0.04]). The gene discussed is SORT1; the disease is coronary artery disorder.