PCSK9 and coronary artery disorder: Similarly, GWAS of Factor 16 captures known lipid biology, with many of the 33 significant loci mapped to core lipid metabolism genes such as LPA, LPL, LDLR, SORT1, APOE and PCSK9 (Fig. 3d), and exhibits strong genetic correlation with a previous coronary artery disease GWAS33 (rg = 0.87[0.02]; InterceptGcov = 0.42[0.01]; UKB-excluded rg = 0.81[0.04]).