DNMT3A and myelodysplastic syndrome: A multivariate Cox regression model for intensively treated patients identified the following independent pretreatment variables regarding OS: age > 60 years (HR 2.1, p = 0.001), secondary AML after MDS (HR 2.2, p = 0.043), DNMT3A-mut (HR 2.1, p = 0.047), KRAS-mut (HR 2.0, p = 0.005), as shown in Fig. 4.