Loss of ABL1 autoregulation contributes to the constitutive activation of BCR::ABL1, driven by homo-oligomerisation of BCR::ABL1 mediated by the coiled-coil domain of the breakpoint cluster region (BCR) protein [3], which in turn induces uncontrolled proliferation and survival of leukemia stem cells. The gene discussed is ABL1; the disease is leukemia.