While the EAE model used herein provides valuable insights into certain aspects of multiple sclerosis, it nevertheless has some limitations in fully recapitulating all aspects of multiple sclerosis, such as the lack of the chronic and progressive nature of multiple sclerosis, and it focuses on an immune response based on CD4+ T cells that are mainly directed to the spinal cord, while multiple sclerosis is primarily driven by CD8+ T cells71. Here, CD4 is linked to multiple sclerosis.