Cholinergic insufficiency is linked to Alzheimer's disease, and several cholinesterase inhibitors have been created to treat it, including naturally produced inhibitors, synthetic analogs, and hybrids such as Acetylcholinesterase (AChE) and Beta site amyloid precursor protein cleaving enzyme 1 (BACE1). The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.