To evaluate the prevalence of aberrant TWEAK/Fn14 signalling in patients with TNBC, we interrogated the TCGA BRCA RNA-seq dataset which revealed the overexpression of Fn14 in basal-like tumours, the predominant molecular subtype of TNBC, relative to ER-positive tumours (Fig. 1a). The gene discussed is ESR1; the disease is neoplasm.