These differential accessible regions displayed corresponding enhanced or depleted accessible chromatin elements in Fn14-high TNBC tumours (2086, 8370, 2063, 6122, 8850 and 5929) relative to matched normal tissues, implying that TWEAK/Fn14-driven chromatin remodelling may be impacting TNBC development. The gene discussed is TNFSF12; the disease is neoplasm.