Moreover, TWEAK treatment selectively induced NAMPT expression in TNBC but not HER2 or ER-positive cell lines (Fig. 6a, Supplementary Fig. 13a), correlating with the elevated levels of NAMPT in Fn14-high TNBC tumours relative to matched normal tissues (Fig. 6b, Supplementary Fig. 13b). Here, TNFRSF12A is linked to neoplasm.